Reginato A J, Schumacher H R, Brighton C T
Arthritis Rheum. 1982 Oct;25(10):1239-49. doi: 10.1002/art.1780251013.
Intraarticular calciphylaxis with cartilage and synovial calcification was produced in rabbits by oral administration of a single dose of dehydrotachysterol followed by an intraarticular injection of ferrous chloride. Synovial membrane apatite deposits were seen in the interstitium, on collagen fibers, and within cell vacuoles. In contrast, long-term administration of dehydrotachysterol alone induced only articular cartilage calcification. Such calcification was limited to the mid and deep zone of cartilage. Most calcium deposits were apatite-like crystals. Acute crystal-associated inflammation was not demonstrated in these specimens with crystals sequestered in synovial or cartilage tissue. Further studies on these models will examine the relation of apatite to joint disease.
通过口服单剂量的脱氢速甾醇，随后关节内注射氯化亚铁，在兔子身上产生了伴有软骨和滑膜钙化的关节内钙质沉着症。在间质、胶原纤维上以及细胞空泡内可见滑膜膜磷灰石沉积。相比之下，单独长期给予脱氢速甾醇仅诱导关节软骨钙化。这种钙化局限于软骨的中层和深层区域。大多数钙沉积物为磷灰石样晶体。在这些晶体包埋于滑膜或软骨组织的标本中未显示急性晶体相关炎症。对这些模型的进一步研究将探讨磷灰石与关节疾病的关系。
