McClure J
J Pathol. 1984 Jan;142(1):15-22. doi: 10.1002/path.1711420106.
Local calcergy is an ectopic calcification reaction (due to hydroxyapatite formation) induced in connective tissue sites by the application of dilute solutions of certain metallic salts (calcergens). The phenomenon is usually produced in the subcutaneous tissues of the experimental animal. The single intra-articular injection of lead acetate (PbAc) solution (a known calcergen) into the knee joint of the rat is followed by opacity of the synovial membrane and para-articular tissues with the aggregation of macrophages and multinucleated giant cells and the formation of some granulation tissue. This lesion ultimately resolves and there is no cartilaginous degeneration. Repeated intra-articular injections of PbAc produce pronounced changes in the synovium and para-articular tissues. There is extensive calcific deposition with exuberant macrophage and giant cell accumulation and fibroblastic proliferation. The proliferated synovial membrance becomes adherent to articular cartilage. There is thinning and fragmentation of the latter with focal loss and replacement by fibrous tissue. Therefore, in contrast to the effects of a single injection, repeated calcergenic stimulation of the knee joint is associated with a destructive arthropathy.
局部钙沉着是通过应用某些金属盐（钙沉着剂）的稀溶液在结缔组织部位诱导产生的异位钙化反应（由于羟基磷灰石形成）。这种现象通常在实验动物的皮下组织中产生。将醋酸铅（PbAc）溶液（一种已知的钙沉着剂）单次关节内注射到大鼠膝关节后，滑膜和关节周围组织会出现浑浊，伴有巨噬细胞和多核巨细胞聚集以及一些肉芽组织形成。这种病变最终会消退，不会出现软骨退变。重复关节内注射PbAc会使滑膜和关节周围组织产生明显变化。会有广泛的钙化沉积，伴有大量巨噬细胞和巨细胞积聚以及成纤维细胞增殖。增生的滑膜会与关节软骨粘连。后者会变薄并破碎，出现局部缺失并被纤维组织替代。因此，与单次注射的效果相反，对膝关节反复进行钙沉着剂刺激会导致破坏性关节病。
