Schrauzer G N, White D A, McGinness J E, Schneider C J, Bell L J
Bioinorg Chem. 1978 Sep;9(3):245-53. doi: 10.1016/s0006-3061(78)80005-2.
The joint administration of 2 ppm of arsenic as arsenite and of 2 ppm of selenium as selenite in the drinking water of inbred female C3H/St mice increases the incidence of spontaneous mammary adenocarcinoma significantly over the simultaneous controls and animals receiving 2 ppm As as arsenite or 2 ppm Se as selenite alone, indicating that arsenic abolishes the anticarcinogenic effect of selenium. Arsenite caused a significant increase of the tumor growth rates and raised the incidence of multiple tumors. The tumor growth rates in the As-Se group were also increased, but the incidence of multiple tumors was lower than in the 2 ppm As group.
在近交系雌性C3H/St小鼠的饮用水中联合给予2 ppm亚砷酸盐形式的砷和2 ppm亚硒酸盐形式的硒，与同时设置的对照组以及单独给予2 ppm亚砷酸盐形式的砷或2 ppm亚硒酸盐形式的硒的动物相比，可显著增加自发性乳腺腺癌的发生率，这表明砷消除了硒的抗癌作用。亚砷酸盐使肿瘤生长速率显著增加，并提高了多发性肿瘤的发生率。砷 - 硒组的肿瘤生长速率也有所增加，但多发性肿瘤的发生率低于2 ppm砷组。
