Koenig J I, Mayfield M A, McCann S M, Krulich L
Neuroendocrinology. 1982 Oct;35(4):277-81. doi: 10.1159/000123394.
Neurotensin (NT) when injected in a dose of 5 micrograms into the third cerebral ventricle of conscious, unrestrained male rats, outfitted with chronic third ventricle and jugular cannulae, decreased the resting prolactin (PRL) levels. NT (5 micrograms) also markedly inhibited the PRL-releasing effect of activation of central serotonin receptors by 5-hydroxytryptophan (5HTP, 15 mg/kg) in animals pretreated with fluoxetine (4 mg/kg). however, interruption of dopamine (DA) neurotransmission by either alpha-methyl-p-tyrosine (alpha MT, 250 mg/kg) or spiroperidol (0.3 mg/kg) led to a blockade of the PRL-inhibiting effect of NT. Treatment of animal with alpha MT prior to the injection of fluoxetine and 5HTP also blocked the PRL-inhibiting effect of NT. These results suggest that the central dopaminergic system mediates the PRL-inhibitory effect of NT.
将神经降压素（NT）以5微克的剂量注入清醒、未受束缚的雄性大鼠的第三脑室，这些大鼠配备有慢性第三脑室和颈静脉插管，结果显示静息催乳素（PRL）水平降低。在预先用氟西汀（4毫克/千克）处理的动物中，NT（5微克）也显著抑制了5-羟色氨酸（5HTP，15毫克/千克）激活中枢5-羟色胺受体所产生的PRL释放效应。然而，通过α-甲基-p-酪氨酸（αMT，250毫克/千克）或螺哌啶醇（0.3毫克/千克）中断多巴胺（DA）神经传递会导致NT的PRL抑制效应被阻断。在注射氟西汀和5HTP之前用αMT处理动物也会阻断NT的PRL抑制效应。这些结果表明，中枢多巴胺能系统介导了NT的PRL抑制效应。
