Ramarli D, Canonica G W, Melioli G, Biagioni P, Nieri S, Casini A, Surrenti C
Scand J Immunol. 1982 Sep;16(3):201-7. doi: 10.1111/j.1365-3083.1982.tb00715.x.
Primary biliary cirrhosis (PBC) is a chronic cholestatic progressive liver disease frequently associated with various immunological abnormalities. We have studied the influence of normal and PBC adherent cells (AC) on peripheral blood lymphocytes (PBL) colony growth both in liquid and soft agar culture. Co-culture experiments with different combinations of AC and PBL of PBC patients and normal donors provided evidence that PBC adherent cells function abnormally. However, this impaired function is not the sole factor involved, since the number of colonies formed by PBC lymphocytes in the presence of normal AC was twice the normal value. The possibility that this increase is correlated with the state of activation of T cells is discussed in the light of the high number of DR-positive T cells found in the PBC patients studied. Finally, none of these immunological abnormalities was related to the stage of the disease.
原发性胆汁性肝硬化（PBC）是一种慢性进行性胆汁淤积性肝病，常伴有各种免疫异常。我们研究了正常和PBC贴壁细胞（AC）在液体和软琼脂培养中对外周血淋巴细胞（PBL）集落生长的影响。对PBC患者和正常供体的AC与PBL的不同组合进行共培养实验，结果表明PBC贴壁细胞功能异常。然而，这种功能受损并非唯一涉及的因素，因为在正常AC存在的情况下，PBC淋巴细胞形成的集落数量是正常值的两倍。鉴于在所研究的PBC患者中发现大量DR阳性T细胞，讨论了这种增加与T细胞活化状态相关的可能性。最后，这些免疫异常均与疾病阶段无关。
