Vaginal Candida albicans treated with three different concentrations of natamycin (Pimafucin) for 6 days.

In 88 patients with vaginal Candida albicans a treatment was performed with natamycin vaginal cream for 6 days in daily doses of 5 ml at concentrations 25 mg natamycin/5 ml (Pim-25), 50 mg natamycin/5 ml (Pim-50), and 100 mg natamycin/5 ml (Pim-100). The cure rates, assessed according to negative cultures of swabs 4-7 days after discontinuation of the treatment, were 89.3%, 85.7%, and 96.9% respectively. Swabs taken about 2 weeks after the next menstrual period showed cure rates of 67.9%, 67.9%, and 78.1% respectively. There was no statistically significant difference in the results between the three groups at the 5% level in Fisher's exact test. The recurrence rate was high in all three groups.