Paret R S, Kumashiro R, Kodama Y, Matsumoto T
Am Surg. 1982 Nov;48(11):594-8.
Several doses of dipyridamomle were tested to assess a reduction in gastric bleeding and ulcer formation in rats exposed to cold stress restraint. When saline was compared to 12.5 mg/kg dipyridamole and 50 units/kg heparin, dipyridamole was significantly better than saline controls (P less than 0.05) in the reduction of both gastric bleeding and gastric ulceration, while the effects of heparin were not significant in either case. Finally, mean hematocrit, platelet count, and gastric acid secretion were not significantly affected by the dose of dipyridamole used (12.5 mg/kg). The results of this study show dipyridamole to be useful in the reduction of both stress ulceration and gastric bleeding induced in rats by cold stress restraint.
测试了几剂双嘧达莫，以评估其对暴露于冷应激约束的大鼠胃出血和溃疡形成的减少作用。当将生理盐水与12.5毫克/千克双嘧达莫和50单位/千克肝素进行比较时，双嘧达莫在减少胃出血和胃溃疡方面明显优于生理盐水对照组（P小于0.05），而肝素在这两种情况下的效果均不显著。最后，所用双嘧达莫剂量（12.5毫克/千克）对平均血细胞比容、血小板计数和胃酸分泌均无显著影响。本研究结果表明，双嘧达莫可有效减少冷应激约束诱导的大鼠应激性溃疡和胃出血。
