前T细胞对新西兰黑鼠体内产生的天然胸腺细胞毒性自身抗体的敏感性。

Sensitivity of pre-T cells to natural thymocytotoxic autoantibodies developed in New Zealand Black mice.

作者信息

Imai Y, Osawa T

出版信息

Clin Exp Immunol. 1982 Sep;49(3):572-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536708/

Abstract

The effect of affinity purified natural thymocytotoxic autoantibodies from New Zealand Black (NZB) mice (NTA-1 and NTA-2) against pre-T cells was studied. Pre-treatment of spleen cells from nu/nu mice or bone marrow cells from DBA/2 mice with NTA-1 and complement (C) or with NTA-2 and C markedly inhibited the induction of T cell markers with a thymic extract in vitro. The effect of NTA-2 and C was abolished by absorption of NTA-2 with neuraminidase treated thymocytes, whereas its effect was not abolished by absorption with intact thymocytes. The effect of NTA-1 and C was abolished by absorption of NTA-1 with either neuraminidase treated thymocytes or intact thymocytes. The effect of NTA-2 was inhibited by lactose whereas the effect of NTA-1 was not. These results suggest that NTA-2 specifically recognizes the cell surface characteristics of pre-T cells and blocks the differentiation pathway of T cells.

摘要

研究了从新西兰黑（NZB）小鼠中亲和纯化得到的天然胸腺细胞毒性自身抗体（NTA - 1和NTA - 2）对前T细胞的作用。用NTA - 1和补体（C）或用NTA - 2和C预处理裸鼠的脾细胞或DBA/2小鼠的骨髓细胞，在体外能显著抑制胸腺提取物诱导T细胞标志物的产生。用神经氨酸酶处理的胸腺细胞吸附NTA - 2后，NTA - 2和C的作用消失，而用完整胸腺细胞吸附则其作用不消失。用神经氨酸酶处理的胸腺细胞或完整胸腺细胞吸附NTA - 1后，NTA - 1和C的作用均消失。乳糖可抑制NTA - 2的作用，而对NTA - 1的作用无抑制效果。这些结果表明，NTA - 2能特异性识别前T细胞的细胞表面特征并阻断T细胞的分化途径。

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