关于新西兰黑鼠（NZB）对H-2相同细胞的T细胞高反应性。初次反应特征及辅助潜能增加的证据。
On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potential.
作者信息
Stockinger B, Botzenhardt U
出版信息
J Exp Med. 1980 Aug 1;152(2):296-305. doi: 10.1084/jem.152.2.296.
Abstract
Experimental evidence presented in this paper suggests that the T cell hyperreactivity of NZB mice against H-2 identical target cells is a true primary response and not the consequence of an in vivo T cell autoimmune priming event. Based on additional data, we believe an elevated potential of T cell help to be present in NZB mice, which facilitates the observed hyperreactivity F1 hybrids of NZB and normal strains of mice inherited the capacity to hyperreact against H-2 identical cells in an H-2-unrestricted fashion. Because the hybrids tested possess both Qa-1 alleles--Qa-1b and Qa-1a--our experiments either indicate the existence of heterogeneity within the Qa-1b system or of an H-2-unrestricted response against additional target antigens. The T cell hyperreactivity might prove to be a valuable tool in further investigations of the pathomechanism of autoimmune disease.
摘要
本文中呈现的实验证据表明，NZB小鼠针对H-2相同靶细胞的T细胞高反应性是一种真正的初级反应，而非体内T细胞自身免疫致敏事件的结果。基于其他数据，我们认为NZB小鼠体内存在增强的T细胞辅助潜能，这促成了所观察到的高反应性。NZB与正常小鼠品系的F1杂种继承了以H-2非限制性方式针对H-2相同细胞产生高反应的能力。由于所测试的杂种同时拥有两个Qa-1等位基因——Qa-1b和Qa-1a——我们的实验要么表明Qa-1b系统内存在异质性，要么表明存在针对其他靶抗原的H-2非限制性反应。T细胞高反应性可能会被证明是进一步研究自身免疫疾病发病机制的一个有价值的工具。
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On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potential.关于新西兰黑鼠（NZB）对H-2相同细胞的T细胞高反应性。初次反应特征及辅助潜能增加的证据。
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本文引用的文献
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Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen.同种异体刺激可调节T细胞对移植抗原的体外反应。
Nature. 1974 May 17;249(454):275-6. doi: 10.1038/249275a0.
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Pathogenesis of autoimmunity in New Zealand mice. V. Loss of thymic suppressor function.新西兰小鼠自身免疫性的发病机制。V. 胸腺抑制功能丧失。
Arthritis Rheum. 1974 Jan-Feb;17(1):11-4. doi: 10.1002/art.1780170103.
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J Exp Med. 1975 Jun 1;141(6):1390-9. doi: 10.1084/jem.141.6.1390.
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Qa-1-associated antigens. II. Evidence for functional differentiation from H-2K and H-2D antigens.Qa-1相关抗原。II. 与H-2K和H-2D抗原功能分化的证据。
J Immunol. 1979 Sep;123(3):1239-44.
6
Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.新西兰黑小鼠针对主要组织相容性复合体同基因未修饰靶标的原发性体外细胞介导的淋巴细胞溶解反应。
J Exp Med. 1978 May 1;147(5):1435-48. doi: 10.1084/jem.147.5.1435.
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