一种人类恶性T淋巴细胞系产生的白血病衍生生长因子（非白细胞介素2）
Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line.
作者信息
Uittenbogaart C H, Fahey J L
出版信息
Proc Natl Acad Sci U S A. 1982 Nov;79(22):7004-8. doi: 10.1073/pnas.79.22.7004.
Abstract
A growth factor was found in the supernatants of MOLT-4f, a cell line derived from acute T lymphoblastic leukemia. This factor, which we designated leukemia-derived growth factor from MOLT-4f (LDGF-M4), is different from interleukin 2. LDGF-M4 has features of a polypeptide with a molecular weight in the range of 5,000-15,000, as indicated by gel diffusion chromatography. LDGF-M4 does stimulate MOLT-4f and at least two other T cell lines that do not respond to interleukin 2. Because MOLT-4f cells produce and respond to LDGF-M4, this factor may contribute to the independence of MOLT-4f and related T leukemia cell lines.
摘要
在源自急性T淋巴细胞白血病的细胞系MOLT-4f的上清液中发现了一种生长因子。我们将这种因子命名为源自MOLT-4f的白血病衍生生长因子（LDGF-M4），它不同于白细胞介素2。如凝胶扩散色谱所示，LDGF-M4具有分子量在5000至15000范围内的多肽特征。LDGF-M4确实能刺激MOLT-4f以及至少另外两种对白细胞介素2无反应的T细胞系。由于MOLT-4f细胞产生并对LDGF-M4作出反应，这种因子可能有助于MOLT-4f及相关T白血病细胞系的自主性。
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