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2
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J Natl Cancer Inst. 1982 Nov;69(5):1077-82.
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Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.成人T细胞白血病衍生因子/硫氧还蛋白由I型人嗜T细胞病毒和爱泼斯坦-巴尔病毒转化的淋巴细胞产生，作为一种自分泌生长因子，并与白细胞介素1和白细胞介素2协同作用。
Proc Natl Acad Sci U S A. 1990 Nov;87(21):8282-6. doi: 10.1073/pnas.87.21.8282.
6
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Conditions affecting clonal growth of lymphoma cells in a semisolid matrix.影响淋巴瘤细胞在半固体基质中克隆生长的条件。
In Vitro Cell Dev Biol. 1985 May;21(5):266-70. doi: 10.1007/BF02620940.
2
Autocrine growth and progression of murine X-ray-induced T cell lymphomas.小鼠X射线诱导的T细胞淋巴瘤的自分泌生长与进展
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3
In vitro malignant progression of cells derived from Abelson murine leukaemia virus-induced thymic lymphomas.源自艾贝尔逊鼠白血病病毒诱导的胸腺淋巴瘤的细胞的体外恶性进展。
Br J Cancer. 1988 Aug;58(2):152-7. doi: 10.1038/bjc.1988.183.
4
N-terminal amino acid sequence of leukemia derived growth factor (LGF) from human erythroleukemia cell culture.来自人红白血病细胞培养物的白血病衍生生长因子（LGF）的N端氨基酸序列。
In Vitro Cell Dev Biol. 1987 Apr;23(4):317-22. doi: 10.1007/BF02623717.

本文引用的文献

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Human T-lymphocyte growth factor: regulation of growth and function of T lymphocytes.人T淋巴细胞生长因子：T淋巴细胞生长和功能的调节
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Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line.一种人类恶性T淋巴细胞系产生的白血病衍生生长因子（非白细胞介素2）
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T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells.T细胞生长因子基因：在人类T细胞白血病-淋巴瘤病毒感染的细胞中缺乏表达。
Science. 1984 Mar 9;223(4640):1086-7. doi: 10.1126/science.6320374.
9
Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.逆转录病毒转化的啮齿动物成纤维细胞和人黑色素瘤细胞产生的转化生长因子：与表皮生长因子的氨基酸序列同源性。
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Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.表皮生长因子对A431细胞的生长刺激作用：利用抗受体单克隆抗体鉴定表皮生长因子的高亲和力受体
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小鼠淋巴瘤T细胞系产生的白血病衍生生长因子（非白细胞介素-2）

Leukemia-derived growth factor (non-interleukin-2) produced by murine lymphoma T-cell lines.

作者信息

Hays E F, Goodrum D, Bessho M, Kitada S, Uittenbogaart C H

出版信息

Proc Natl Acad Sci U S A. 1984 Dec;81(24):7807-11. doi: 10.1073/pnas.81.24.7807.

DOI:10.1073/pnas.81.24.7807
PMID:6595661
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392241/
Abstract

Autocrine growth factor activity was found in supernatants of AKR T-cell lymphoma lines cultured in serum-free medium. This factor was designated leukemia-derived growth factor (LDGF). Active supernatants stimulated the growth of the AKR murine T-cell lymphoma line SL 12, its cloned derivatives, and all other murine T-cell lymphoma lines tested. Growth factor activity in conditioned medium was found to be different from interleukin 2 (IL-2) and several other known growth factors. LDGF was able to stimulate growth of the human leukemia T-cells MOLT4f, and the LDGF from MOLT4f cells stimulated the mouse cells. Because mouse T-cell lymphoma lines produced and respond to this factor, it may support the continued proliferation of these cells and could be responsible for their malignant in vivo properties.

摘要

在无血清培养基中培养的AKR T细胞淋巴瘤细胞系的上清液中发现了自分泌生长因子活性。这种因子被命名为白血病衍生生长因子（LDGF）。活性上清液刺激了AKR小鼠T细胞淋巴瘤细胞系SL 12、其克隆衍生物以及所有其他测试的小鼠T细胞淋巴瘤细胞系的生长。发现条件培养基中的生长因子活性不同于白细胞介素2（IL-2）和其他几种已知的生长因子。LDGF能够刺激人白血病T细胞MOLT4f的生长，而来自MOLT4f细胞的LDGF则刺激小鼠细胞。由于小鼠T细胞淋巴瘤细胞系产生并对这种因子有反应，它可能支持这些细胞的持续增殖，并可能导致它们在体内的恶性特性。