左旋咪唑对人T淋巴细胞体外集落形成能力的增强作用。
Enhancement of the in vitro colony-forming capacity of human T lymphocytes induced by levamisole.
作者信息
Pistoia V, Ghio R, Dallegri F, Patrone F
出版信息
Thymus. 1982 Sep;4(5):273-8.
The colony-forming capacity of normal peripheral blood mononuclear cells and of TG-depleted cell suspensions induced by PHA was investigated in the presence of different concentrations of levamisole. The results obtained demonstrate that: (1) the drug enhances significantly the number of colonies formed by both mononuclear cells and TG-depleted cells at concentrations ranging from 5 x 10(-6) to 5 x 10(-8 M; (2) this stimulatory activity results from a direct effect on T cells; and (3) adherent accessory cells are unaffected by the in vitro treatment with levamisole.
在不同浓度的左旋咪唑存在的情况下，研究了正常外周血单核细胞和PHA诱导的TG耗尽细胞悬液的集落形成能力。获得的结果表明：（1）在5×10⁻⁶至5×10⁻⁸M的浓度范围内，该药物显著增加了单核细胞和TG耗尽细胞形成的集落数量；（2）这种刺激活性源于对T细胞的直接作用；（3）贴壁辅助细胞不受左旋咪唑体外处理的影响。
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