Gerber M, Pioch Y, Dubois J B, Serrou B
IARC Sci Publ. 1982(39):279-89.
A T-cytotoxic response was demonstrated in a non-productive, viral-induced syngeneic tumoural system in vitro, but it did not result in tumour rejection: When tumour cell inoculum was removed surgically early after transplantation and processed, a specific T-cell-mediated cytotoxic response was observed in vitro and in the Winn assay; however, a tumour-cell challenge was rejected, showing that under certain conditions, the immune response can modify tumour evolution. Localized irradiation was administered according to one of two protocols (7 Gy X 3 over a week and 4 Gy X 3 over 3 weeks). The cumulative dose of the latter regimen was nearly 20% greater than that of the former; however, the outcomes of the two therapies were dramatically different: 50% survival in group 2, and a short delay in tumour growth in group 1. The scattered dose (of around 0.15 Gy) delivered to the spleen in the first group decreased the T-cytotoxic response, but that in the second group (scattering inferior to 0.07 Gy) did not. The similarity in therapeutic results in the two groups when the irradiation regimens were preceded by immunosuppression suggests that this failure of the immune response could influence the outcome of radiotherapy. The effect of low doses of irradiation on tumour rejection was also studied in an allogeneic system.
在体外非增殖性病毒诱导的同基因肿瘤系统中证实了细胞毒性T细胞反应，但这并未导致肿瘤排斥：当在移植后早期通过手术切除肿瘤细胞接种物并进行处理时，在体外和Winn试验中观察到了特异性T细胞介导的细胞毒性反应；然而，肿瘤细胞攻击被排斥，这表明在某些条件下，免疫反应可以改变肿瘤的发展。根据两种方案之一进行局部照射（一周内7 Gy×3次和3周内4 Gy×3次）。后一种方案的累积剂量比前一种方案高近20%；然而，两种治疗的结果却大不相同：第2组生存率为50%，第1组肿瘤生长仅短暂延迟。第一组中传递至脾脏的散射剂量（约0.15 Gy）降低了细胞毒性T细胞反应，但第二组（散射低于0.07 Gy）则没有。在免疫抑制之前采用照射方案时，两组治疗结果的相似性表明，这种免疫反应的失败可能会影响放射治疗的结果。还在同种异体系统中研究了低剂量照射对肿瘤排斥的影响。
