Gerber M, Dubois J B, Gauci L, Serrou B
Ann Immunol (Paris). 1979 Sep-Oct;130C(5):735-42.
The effect of localized irradiation given as single dose on the immune response of tumour-bearing mice was evaluated using the CRT. The tumour system (MBL2 on C57BL/6 females) was regularly lethal, although presence of CTL was demonstrated 15 days after transplantation (50,000 cells in the left hind limb). This T-dependent, antigen-specific cytotoxic activity observed on day 15 in the non-irradiated tumour-bearing group was abolished in the irradiated group (but not in the sham-irradiated group) and their CTL were incapable to mount a secondary response in MLTC-CML. The scattering of the 1,600 rad-single dose was sufficient to provoke this inhibition.
使用细胞毒试验（CRT）评估了单次局部照射对荷瘤小鼠免疫反应的影响。肿瘤模型（C57BL/6雌性小鼠的MBL2）通常是致命的，尽管移植后15天（左后肢接种50,000个细胞）证明有细胞毒性T淋巴细胞（CTL）存在。在未照射的荷瘤组中于第15天观察到的这种依赖T细胞的、抗原特异性细胞毒活性在照射组（但不在假照射组）中被消除，并且它们的CTL在混合淋巴细胞肿瘤细胞培养（MLTC-CML）中无法产生二次反应。1600拉德的单次剂量散射足以引发这种抑制作用。
