Ramot B, Ben-Bassat I, Many A, Kende G, Neuman Y, Brok-Simoni F, Rosenthal E, Orgad S
Leuk Res. 1982;6(5):669-73. doi: 10.1016/0145-2126(82)90083-2.
During the period from 1978 to 1981, 52 patients with ALL were diagnosed and treated at the Chaim Sheba Medical Center. Using standard cell markers to subtype the blasts, 49 of the patients could be classified: 16 were found to be T-cell ALL, 10 common ALL, five null ALL, four pre-B and 14 were partially characterized as non-B, non-T. Analysis of the series revealed two distinctive features: high prevalence (30%) of T-cell ALL among both Jews and Arabs and a high proportion, two-thirds, of high risk patients due to high initial WBC counts, unfavourable age or T-cell characteristics. The minimal incidence of ALL among the Gaza Strip Arab children during the study period is 4:100,000, which is close to the incidence in the Western world. During previous years the leukemia incidence in the Gaza Strip was very low while the most common lymphatic malignancies were Burkitt tumor and other non-Hodgkin lymphomas.
1978年至1981年期间，52例急性淋巴细胞白血病患者在哈伊姆·谢巴医疗中心被诊断和治疗。使用标准细胞标志物对原始细胞进行亚型分类，49例患者可被分类：16例为T细胞急性淋巴细胞白血病，10例为普通急性淋巴细胞白血病，5例为裸细胞急性淋巴细胞白血病，4例为前B细胞急性淋巴细胞白血病，14例部分特征为非B、非T细胞急性淋巴细胞白血病。对该系列病例的分析揭示了两个显著特征：犹太人和阿拉伯人中T细胞急性淋巴细胞白血病的高患病率（30%），以及由于初始白细胞计数高、年龄不利或T细胞特征导致的高风险患者比例较高，达三分之二。研究期间，加沙地带阿拉伯儿童急性淋巴细胞白血病的最低发病率为4/10万，这与西方世界的发病率相近。在过去几年中，加沙地带的白血病发病率非常低，而最常见的淋巴系统恶性肿瘤是伯基特淋巴瘤和其他非霍奇金淋巴瘤。
