Ramot B, Ben-Bassat I, Brecher A, Zaizov R, Modan M
Leuk Res. 1984;8(4):691-9. doi: 10.1016/0145-2126(84)90017-1.
n epidemiologic survey of childhood acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) occurring in Israel, Judea, Samaria and the Gaza Strip between the years 1976 and 1981, revealed 205 cases of ALL and 69 of NHL. The mean annual incidence of lymphatic malignancies was 3.1/10(5) in the Israeli Jews, 2.3/10(5) in the Israeli Arabs and 2.5/10(5) in the Gaza Strip. In the Jewish population there was a peak in the incidence of lymphatic malignancies at the 2-5 years age group, while in the Israeli Arabs this was less prominent. There were no significant differences in the incidence or type of lymphatic malignancies in the various Jewish or Arab groups but there was a trend for a high leukemia to lymphoma ratio (LLR) in the patients from the Gaza Strip. A relatively higher LLR was observed in families of a high socioeconomic status, but it did not reach statistical significance. T-cell ALL comprised about a third of the typed ALL cases. A high proportion of the patients with ALL belonged to the high-risk category: 46% of the Jewish children and 76% of the Gaza Strip children. White blood cell count above 100,000/mm3 were found at presentation in 36.7% of the Gaza Strip patients but only in 9.4% of the Jewish patients. In spite of that, the survival at 4 years of the Jewish and Arab patients was similar. However, the patients with T-cell ALL had a significantly worse survival than the standard risk or the non-T high-risk group: 43.3 +/- 9.7, 66.6 +/- 7.1 and 63.6 +/- 10.4%, respectively. Compared to a previous study conducted in this country in the sixties it appears that the epidemiologic differences that were observed at that time between the various Jewish ethnic groups have practically disappeared.
一项关于1976年至1981年间发生在以色列、犹地亚、撒马利亚和加沙地带的儿童急性淋巴细胞白血病（ALL）和非霍奇金淋巴瘤（NHL）的流行病学调查显示，有205例ALL病例和69例NHL病例。淋巴系统恶性肿瘤的年平均发病率在以色列犹太人中为3.1/10⁵，在以色列阿拉伯人中为2.3/10⁵，在加沙地带为2.5/10⁵。在犹太人群中，淋巴系统恶性肿瘤的发病率在2至5岁年龄组达到峰值，而在以色列阿拉伯人中这一峰值不太明显。不同犹太或阿拉伯群体在淋巴系统恶性肿瘤的发病率或类型上没有显著差异，但加沙地带患者的白血病与淋巴瘤比例（LLR）有升高趋势。在社会经济地位较高的家庭中观察到相对较高的LLR，但未达到统计学意义。T细胞ALL约占已分型ALL病例的三分之一。ALL患者中很大一部分属于高危类别：46%的犹太儿童和76%的加沙地带儿童。加沙地带36.7%的患者在初诊时白细胞计数高于100,000/mm³，而犹太患者中这一比例仅为9.4%。尽管如此，犹太和阿拉伯患者的4年生存率相似。然而，T细胞ALL患者的生存率明显低于标准风险组或非T高危组：分别为43.3±9.7%、66.6±7.1%和63.6±10.4%。与该国在六十年代进行的一项先前研究相比，当时在不同犹太族群之间观察到的流行病学差异实际上已经消失。
