Hakkarainen H, Parantainen J, Gothoni G, Vapaatalo H
Cephalalgia. 1982 Dec;2(4):173-7. doi: 10.1046/j.1468-2982.1982.0204173.x.
Tolfenamic acid is a potent inhibitor of prostaglandin biosynthesis, which has been proved effective in the treatment of acute migraine attacks. The usefulness of caffeine, metoclopramide and pyridoxine as adjuncts to tolfenamic acid was tested in acute migraine attacks in ten patients. A combination of tolfenamic acid (200 mg) with either caffeine (100 mg), metoclopramide (10 mg) or pyridoxine (300 mg) was given twice to each patient in random order. Thus 60 attacks were treated. The tolfenamic acid-caffeine combination proved the most effective as judged by duration and intensity of attacks, working ability, vigilance, and overall evaluation of the drugs by the patients. Metoclopramide was somewhat better than pyridoxine as an additive.
托芬那酸是一种有效的前列腺素生物合成抑制剂，已被证明对治疗急性偏头痛发作有效。在10名患者的急性偏头痛发作中测试了咖啡因、甲氧氯普胺和吡哆醇作为托芬那酸辅助药物的效用。将托芬那酸（200毫克）与咖啡因（100毫克）、甲氧氯普胺（10毫克）或吡哆醇（300毫克）的组合以随机顺序给予每位患者两次。因此共治疗了60次发作。从发作的持续时间和强度、工作能力、警觉性以及患者对药物的总体评价来看，托芬那酸 - 咖啡因组合被证明是最有效的。作为添加剂，甲氧氯普胺比吡哆醇稍好一些。
