Tokola R A
Methods Find Exp Clin Pharmacol. 1985 Oct;7(10):545-50.
Tolfenamic acid is an anti-inflammatory analgesic which is used in the treatment of migraine attacks. Because caffeine is used in certain analgesic combinations, its effects on the absorption of tolfenamic acid was studied in a crossover study in migraine patients. Caffeine did not significantly change the absorption of tolfenamic acid during migraine attacks. The extent of absorption following oral administration of tolfenamic acid is decreased during migraine attacks, irrespectively if the volunteers received caffeine or placebo in combination with the drug. The reasons are discussed. It seems obvious that the migraine itself is responsible for the lack of absorption that cannot be counteracted with caffeine. Pain relief within a five-hour testing period was not influenced by concomitant administration of caffeine. It is concluded that tolfenamic acid alone is sufficient in treating migraines.
托芬那酸是一种抗炎镇痛药，用于治疗偏头痛发作。由于咖啡因被用于某些镇痛组合中，因此在一项针对偏头痛患者的交叉研究中，研究了其对托芬那酸吸收的影响。咖啡因在偏头痛发作期间并未显著改变托芬那酸的吸收。无论志愿者在服用该药物时同时服用咖啡因还是安慰剂，偏头痛发作期间口服托芬那酸后的吸收程度均会降低。文中对其原因进行了讨论。很明显，偏头痛本身导致了吸收不足，而这无法通过咖啡因来抵消。在五小时的测试期内，疼痛缓解情况不受同时服用咖啡因的影响。得出的结论是，单独使用托芬那酸就足以治疗偏头痛。
