Low P A, Schmelzer J, Dyck P J, Kelly J J
Electroencephalogr Clin Neurophysiol Suppl. 1982;36:81-90.
Sera from 10 patients with AIDP and 10 age-matched controls were microinjected into the tibial division of rat sciatic nerve using improved microinjection techniques and coded sera. No statistically significant changes in conduction velocity or amplitude of the compound muscle action potential (CMAP) or in the monophasic compound action potential (CAP) parameters was found at 1 week. In nerves studied with serial recording over 1 h a small but significantly greater reduction in CMAP amplitude was observed at 60 min in the AIDP group and at both 30 and 60 min when only sera from very severely affected (bed-ridden) patients were considered. A similar reduction was found following microinjection into focally demyelinated nerves. The finding of a small reduction in CMAP amplitude in the first hour suggests the presence in some AIDP patients of serum blocking or demyelinating factors but the clinical significance of this small reduction is uncertain.
采用改良的微量注射技术并对血清进行编码，将10例急性炎性脱髓鞘性多发神经病（AIDP）患者和10例年龄匹配的对照者的血清微量注射到大鼠坐骨神经的胫支中。在1周时，复合肌肉动作电位（CMAP）的传导速度或波幅以及单相复合动作电位（CAP）参数均未发现有统计学意义的变化。在连续记录1小时的神经中，AIDP组在60分钟时观察到CMAP波幅有小幅但显著更大程度的降低，而仅考虑来自病情非常严重（卧床）患者的血清时，在30分钟和60分钟时均出现这种情况。在局灶性脱髓鞘神经中进行微量注射后也发现了类似的降低。在第1小时内CMAP波幅有小幅降低这一发现提示，部分AIDP患者血清中存在阻断或脱髓鞘因子，但这种小幅降低的临床意义尚不确定。
