Low P A, Schmelzer J D, Dyck P J
Mayo Clin Proc. 1982 Jun;57(6):360-4.
We previously studied the neurophysiologic effect of endoneural injection of serum from patients with acute inflammatory-demyelinating polyradiculoneuropathy into the sciatic nerve of Sprague-Dawley rats and did not observe a statistically significant difference between the results with that serum and control serum at 1 week. Because of potential strain susceptibility to acute inflammatory-demyelinating polyradiculoneuropathy serum after endoneural injection, the syngeneic Lewis rat--which is more susceptible than other strains of rats to experimental allergic neuritis (considered to be an experimental model of acute inflammatory-demyelinating polyradiculoneuropathy)--was studied. We used sera from five severely affected patients and also used a more sensitive (compared with our earlier studies) electrophysiologic approach that included in vivo monophasic compound action potential recordings and paired pulses. No statistically significant differences in conduction velocity, amplitude, indices of dispersion, or time-integral percentage were found between disease and control sera at 1 week. We conclude that the human acute inflammatory-demyelinating polyradiculoneuropathy serum tested did not contain measurable demyelinating activity for rat nerve in excess of that of control serum.
我们之前研究了将急性炎性脱髓鞘性多发性神经根神经病患者的血清经神经内膜注射到Sprague-Dawley大鼠坐骨神经中的神经生理学效应，在1周时未观察到该血清与对照血清的结果之间存在统计学显著差异。由于经神经内膜注射后可能存在对急性炎性脱髓鞘性多发性神经根神经病血清的品系易感性，因此研究了同基因的Lewis大鼠，该品系大鼠比其他品系大鼠对实验性变应性神经炎（被认为是急性炎性脱髓鞘性多发性神经根神经病的实验模型）更易感。我们使用了5名重症患者的血清，并采用了一种更敏感的（与我们早期研究相比）电生理方法，包括体内单相复合动作电位记录和双脉冲。在1周时，疾病血清与对照血清之间在传导速度、波幅、离散指数或时间积分百分比方面未发现统计学显著差异。我们得出结论，所检测的人类急性炎性脱髓鞘性多发性神经根神经病血清对大鼠神经的脱髓鞘活性未超过对照血清，无法检测到。
