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急性炎症性多发性神经根神经病患者血清的神经内膜效应:对正常和脱髓鞘大鼠神经的电生理研究

Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: electrophysiologic studies on normal and demyelinated rat nerves.

作者信息

Low P A, Schmelzer J, Dyck P J, Kelly J J

出版信息

Neurology. 1982 Jul;32(7):720-4. doi: 10.1212/wnl.32.7.720.

DOI:10.1212/wnl.32.7.720
PMID:7201109
Abstract

Serum from 10 patients with acute inflammatory demyelinative polyradiculoneuropathy (AIDP) and 10 age-matched controls was injected into rat sciatic nerve. No statistically significant changes in any electrophysiologic parameters were found at 1 week. In nerves studied with serial recordings over 60 minutes, a small but significantly greater reduction in compound muscle action potential (CMAP) was observed at 60 minutes with AIDP serum injected into normal or focally demyelinated nerves. The small reduction in CMAP amplitude in the first hour is of uncertain clinical significance.

摘要

将10例急性炎性脱髓鞘性多发性神经根神经病(AIDP)患者及10例年龄匹配的对照者的血清注入大鼠坐骨神经。1周时未发现任何电生理参数有统计学意义的变化。在60分钟内进行连续记录研究的神经中,将AIDP血清注入正常或局灶性脱髓鞘神经后,在60分钟时观察到复合肌肉动作电位(CMAP)有轻微但显著更大程度的降低。最初1小时内CMAP幅度的轻微降低,其临床意义尚不确定。

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Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: electrophysiologic studies on normal and demyelinated rat nerves.急性炎症性多发性神经根神经病患者血清的神经内膜效应:对正常和脱髓鞘大鼠神经的电生理研究
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