蛋白酶抑制剂（α1-抗胰蛋白酶）亚型：几种人群中PI*M4的频率。
PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations.
作者信息
Klasen E C, Bos A, Simmelink H D
出版信息
Hum Genet. 1982;62(2):139-41. doi: 10.1007/BF00282302.
Sera from different populations (Dutch, Northern and Southern Italians and Spaniards) were screened for PI (alpha 1-antitrypsin) types and subtypes. A polyacrylamide isoelectric focusing method was applied, which consisted of the combined use of an ultra-thin highly cross-linked gel, restricted pH range carrier ampholytes and a separator. This technique enabled easy typing and subtyping of all known PI phenotypes including PIM subtypes. The frequency of the new PIM4 allele was lowest of all PI*M alleles (0.0476 in The Netherlands, 0.0371 in Northern Italy, 0.0308 in Southern Italy and 0.0146 in Spain).
对来自不同人群（荷兰人、意大利北部和南部人以及西班牙人）的血清进行了蛋白酶抑制剂（α1-抗胰蛋白酶）类型和亚型的筛查。采用了一种聚丙烯酰胺等电聚焦方法，该方法包括联合使用超薄高度交联凝胶、受限pH范围的载体两性电解质和一种分离器。这项技术能够轻松地对所有已知的蛋白酶抑制剂表型进行分型和亚型鉴定，包括PIM亚型。新的PIM4等位基因的频率在所有PI*M等位基因中是最低的（在荷兰为0.0476，在意大利北部为0.0371，在意大利南部为0.0308，在西班牙为0.0146）。
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