西班牙的α1抗胰蛋白酶与乳糜泻
alpha 1-Antitrypsin and coeliac disease in spain.
作者信息
Klasen E C, Polanco I, Biemond I, Vazquez C, Peña A S
出版信息
Gut. 1980 Nov;21(11):948-50. doi: 10.1136/gut.21.11.948.
Abstract
Ninety-three Spanish children suffering from coeliac disease and 103 control subjects from the same area were screened for the amount of alpha 1-antitrypsin (alpha 1AT) and for any electrophoretic variations in it. In this case-control study no significant differences were detected either in phenotype distribution or amount. The present results indicate that no genetic association exists between alpha 1AT and coeliac disease.
摘要
对93名患有乳糜泻的西班牙儿童和来自同一地区的103名对照受试者进行了α1-抗胰蛋白酶（α1AT）含量及其任何电泳变异的筛查。在这项病例对照研究中，未在表型分布或含量方面检测到显著差异。目前的结果表明，α1AT与乳糜泻之间不存在遗传关联。
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本文引用的文献
1
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Hum Genet. 1980;53(3):429-33. doi: 10.1007/BF00287070.
2
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
3
Population genetic studies of serum protein polymorphisms in four Spanish populations. II.四个西班牙人群血清蛋白多态性的群体遗传学研究。II.
Hum Hered. 1973;23(2):135-46. doi: 10.1159/000152565.
4
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J Lab Clin Med. 1969 Jun;73(6):934-9.
5
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Lancet. 1972 Oct 21;2(7782):883-4. doi: 10.1016/s0140-6736(72)92258-1.
6
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JAMA. 1975 Jan 20;231(3):273-6.
7
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8
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9
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10
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