Richter M, Markwardt F, Klöcking H P
Pharmazie. 1982 Dec;37(12):851-3.
In rabbits and rats pharmacokinetic studies on the anti-fibrinolytics 4-aminomethylbenzoic acid (PAMBA), trans-4-aminomethylcyclohexane-1-carboxylic acid (AMCA), and epsilon-aminocaproic acid (EACA) were carried out using the tritium labelled compounds. Following i. v. administration of PAMBA and EACA in rabbits a two-phasic plasma level and following AMCA a three-phasic plasma level was found within 7 h. The rate constants beta of 0.34 h-1, 0.44 h-1, and 1.08 h-1 for EACA, PAMBA, and AMCA, respectively, indicate a more rapid elimination of AMCA. Accordingly, the AUC-values for AMCA are considerably smaller than those for EACA and PAMBA after both i. v. and p. o. administration.
在兔子和大鼠身上，使用氚标记的化合物对抗纤维蛋白溶解剂4-氨甲基苯甲酸（PAMBA）、反式-4-氨甲基环己烷-1-羧酸（AMCA）和ε-氨基己酸（EACA）进行了药代动力学研究。给兔子静脉注射PAMBA和EACA后，7小时内血浆水平呈双相变化；给兔子静脉注射AMCA后，7小时内血浆水平呈三相变化。EACA、PAMBA和AMCA的消除速率常数β分别为0.34 h⁻¹、0.44 h⁻¹和1.08 h⁻¹，这表明AMCA的消除速度更快。因此，静脉注射和口服给药后，AMCA的AUC值均明显小于EACA和PAMBA的AUC值。
