5-羟-N-乙酰色氨酸（一种假定的N-乙酰血清素合成前体）的行为效应。

Behavioral effects of 5-hydroxy-N-acetyltryptophan, a putative synthetic precursor of N-acetylserotonin.

Burns T G, Szechtman H, Brown G M, Snieckus V

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):359-63. doi: 10.1016/s0278-5846(82)80107-3.

Abstract

Adult male rats were injected with either 5-hydroxy-N-acetyltryptophan (5-OHNAT), a synthetic putative precursor of N-acetylserotonin, or 5-hydroxytryptophan (5-HTP), the serotonin precursor, and behavioral effects were observed. Pretreatment consisted of carbidopa and nialamide. 2. The behavioral effects of systemic injections of 5-OHNAT and 5-HTP were qualitatively similar i.e. head weaving, forepaw treading, etc., but the effect of 5-OHNAT was appreciably delayed in onset. 3. 5-OHNAT loading may cause an increase in central nervous system 5-HT via initial deacetylation to 5-HTP. Alternatively, 5-OHNAT may cause a delayed increase in brain NAS and the "serotonin syndrome" may reflect increased conversion of 5-HT to NAS.

摘要

给成年雄性大鼠注射5-羟基-N-乙酰色氨酸（5-OHNAT，一种假定的N-乙酰血清素合成前体）或5-羟色氨酸（5-HTP，血清素前体），并观察行为效应。预处理包括卡比多巴和尼亚酰胺。2. 全身注射5-OHNAT和5-HTP的行为效应在性质上相似，即头部摆动、前爪踩踏等，但5-OHNAT的效应起效明显延迟。3. 5-OHNAT负荷可能通过最初脱乙酰化为5-HTP导致中枢神经系统5-羟色胺增加。或者，5-OHNAT可能导致大脑N-乙酰血清素延迟增加，且“血清素综合征”可能反映5-羟色胺向N-乙酰血清素的转化增加。