Mathies H
Z Rheumatol. 1982 Nov-Dec;41(6):241-3.
It is shown that the concept of "seronegative HLA B 27 associated spondarthritis," which is unsatisfactory even as a name, cannot be accepted as a new overgroup in a logically constructed classification. HLA B 27 occurs in certain of these illnesses almost inevitably as a predisposing antigen; in others it is merely a factor modifying the pattern of disease. The illnesses thus are obviously different. In any case, the concept itself is not a diagnosis, in spite of the fact that it is at present often employed as a diagnostic term.
结果表明，“血清阴性HLA B27相关性脊柱关节炎”这一概念，即便作为一个名称也不尽人意，在逻辑构建的分类中不能被接受为一个新的上位组。HLA B27在某些此类疾病中几乎不可避免地作为一种易感抗原出现；在其他疾病中，它仅仅是一个改变疾病模式的因素。因此这些疾病明显不同。无论如何，尽管目前该概念常被用作诊断术语，但它本身并不是一种诊断。
