Weiss J F, Wolf G T, Edwards B K, Chretien P B
Cancer Detect Prev. 1981;4(1-4):211-7.
In patients with solid malignancies, such as those associated with chronic smoking, levels of immunosuppressive acute-phase proteins (haptoglobin, alpha 1-acid glycoprotein, alpha 1-antitrypsin) are increased and correlate directly with extent of tumor and inversely with immune reactivity. Other serum proteins with immunorestorative properties (alpha 2HS-glycoprotein, prealbumin) are decreased and correlate directly with immune reactivity. Serum levels of these glycoproteins and albumin were measured in normal volunteers (132 cigarette smoking and 140 nonsmoking) to determine the effects of smoking history, age, and sex on protein levels. The alpha 1-acid glycoprotein increased, whereas albumin decreased with age in both groups, and haptoglobin increased with age in smokers. The alpha 1-acid glycoprotein, haptoglobin, and albumin levels also correlated with the extent of smoking (pack-years). In a comparison of age- and sex-matched smokers and nonsmokers, alpha 1-antitrypsin uniquely and significantly increased (P less than 0.001) in smokers but was not related to age or extent of smoking. The diagnostic and immunological implications of smoking and age-related changes in serum protein levels are discussed.
在患有实体恶性肿瘤的患者中，如那些与长期吸烟相关的患者，免疫抑制急性期蛋白（触珠蛋白、α1-酸性糖蛋白、α1-抗胰蛋白酶）水平升高，且与肿瘤范围直接相关，与免疫反应性呈负相关。其他具有免疫恢复特性的血清蛋白（α2HS-糖蛋白、前白蛋白）水平降低，且与免疫反应性直接相关。在正常志愿者（132名吸烟者和140名不吸烟者）中测量了这些糖蛋白和白蛋白的血清水平，以确定吸烟史、年龄和性别对蛋白质水平的影响。在两组中，α1-酸性糖蛋白随年龄增加，而白蛋白随年龄降低，触珠蛋白在吸烟者中随年龄增加。α1-酸性糖蛋白、触珠蛋白和白蛋白水平也与吸烟程度（包年数）相关。在年龄和性别匹配的吸烟者和不吸烟者的比较中，α1-抗胰蛋白酶在吸烟者中独特且显著升高（P<0.001），但与年龄或吸烟程度无关。讨论了吸烟和年龄相关的血清蛋白水平变化的诊断和免疫学意义。
