巯基在T淋巴细胞介导的细胞毒性中的作用。
Role of sulphydryl groups in T lymphocyte-mediated cytotoxicity.
作者信息
Thorne K J, Free J, Franks D
出版信息
Clin Exp Immunol. 1982 Dec;50(3):644-50.
Abstract
The role of thiols in T cell-mediated cytotoxicity was investigated by studying the thiols of the target cell and cytotoxic cell separately. Agents which protect the reduced thiols of the target cell inhibit their lysis by the cytotoxic T cells; thiol reactive reagents may be directly toxic to the target cell. The thiol groups of the effector cell are also important, since pre-treatment with thiol reactive reagents inhibits killing.
摘要
通过分别研究靶细胞和细胞毒性细胞的硫醇，探讨了硫醇在T细胞介导的细胞毒性中的作用。保护靶细胞还原型硫醇的试剂可抑制细胞毒性T细胞对其的裂解；硫醇反应性试剂可能对靶细胞具有直接毒性。效应细胞的硫醇基团也很重要，因为用硫醇反应性试剂预处理会抑制杀伤作用。
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