Horikoshi N, Ogawa M
Gan To Kagaku Ryoho. 1982 Nov;9(11):1903-10.
Forty years ago, nitrogen mustard was first used in the treatment of a group of six patients with neoplastic diseases, including lymphosarcoma and Hodgkin's disease at Yale University. Since then different kinds of chemotherapeutic agents have been discovered, which clinical efficacy was reviewed as a single agent and in combination. Especially over the past two decades, the management of malignant lymphoma has improved significantly with combination chemotherapy. Now there are several potentially curative regimens, such as MOPP therapy for Hodgkin's disease, and MOPP (or C-MOPP), CHOP (or HOP), BACOP and COMLA for diffuse histiocytic lymphoma. There are recent trends to include methotrexate in combination and to use two non-cross-resistant regimens alternatively (CVP/ABP, MOPP/ABVD) for improving complete remission rate and remission duration. Treatment for favorable histologies, and clinical features and treatment of adult T-cell leukemia lymphoma were also briefly reviewed.
四十年前，氮芥首次用于治疗一组六名患有肿瘤疾病的患者，其中包括耶鲁大学的淋巴肉瘤和霍奇金病患者。从那时起，人们发现了不同种类的化疗药物，并对其作为单一药物及联合用药时的临床疗效进行了评估。特别是在过去二十年中，联合化疗显著改善了恶性淋巴瘤的治疗效果。现在有几种可能治愈的方案，例如用于霍奇金病的MOPP疗法，以及用于弥漫性组织细胞淋巴瘤的MOPP（或C-MOPP）、CHOP（或HOP）、BACOP和COMLA。最近有将甲氨蝶呤纳入联合用药以及交替使用两种非交叉耐药方案（CVP/ABP、MOPP/ABVD）的趋势，以提高完全缓解率和缓解持续时间。文中还简要回顾了对预后良好的组织学类型的治疗，以及成人T细胞白血病淋巴瘤的临床特征和治疗方法。
