Fujimoto S, Ishigami H, Amemiya K, Ohyama Y, Kure M, Endoh F, Okui K
Gan To Kagaku Ryoho. 1982 Jul;9(7):1237-42.
P-aminobenzoic acid-N-xyloside (K-247) and dimethyl-2- (tetrahydro-2-furanyl) ethylsulfonium-p-toluene sulfonate (GT-101) were tested their in vivo effects on both mitogen-induced lymphoproliferative reactions and natural cell-mediated cytotoxicities in BALB/c nude mice (homozygous and heterozygous) spleen lymphocytes. The animals were injected i.p. either 400 mg/kg of K-247 or 5 mg/kg of GT-101 (for 7 days consecutively). GT-101 caused a positive increase in lymphoproliferations by PHA and SPA, while the administration of K-247 had no effect on PHA-and SPA-induced lymphoproliferations. Furthermore, in a 12-hour 51Cr release assay, both drugs had no effect on the natural cell-mediated cytotoxicity against YAC-1 cells.
对氨基苯甲酸 - N - 木糖苷（K - 247）和对甲苯磺酸 - 2 - （四氢 - 2 - 呋喃基）乙硫鎓二甲酯（GT - 101）在BALB/c裸鼠（纯合子和杂合子）脾淋巴细胞中，针对丝裂原诱导的淋巴细胞增殖反应和天然细胞介导的细胞毒性进行了体内效应测试。给动物腹腔注射400 mg/kg的K - 247或5 mg/kg的GT - 101（连续7天）。GT - 101使PHA和SPA诱导的淋巴细胞增殖呈正向增加，而给予K - 247对PHA和SPA诱导的淋巴细胞增殖没有影响。此外，在12小时的51Cr释放试验中，两种药物对针对YAC - 1细胞的天然细胞介导的细胞毒性均无影响。
