Moretti M, Montali S
Pediatr Med Chir. 1982 Sep-Oct;4(5):481-90.
The neuroactive drugs taken by pregnant women have two principals side effects: a teratogenic effects and a postnatal withdrawal effect. Three are the characteristic syndromes: the hydantoin-barbiturate syndrome, the trimethadione-paramethadione syndrome, the fetal alcohol syndrome. The prenatal exposure to heroine and to morphine interfere mainly with the cerebral development. Drug addiction, like postnatale withdrawal syndrome, are mainly due to passive exposure to drug narcotic (heroine, methadone), to sedative-hypnotic agents (barbiturates Diazepam Chlordiazepoxide) and to alcohol. The cigarette smoke is responsible for third group of side effects, namely for the reduced fetal growth and for the premature labor. No side effects on the human fetus were observed due to abuse of coffee or to use of marihuana during pregnancy.
致畸作用和产后戒断效应。有三种特征性综合征:苯妥英 - 巴比妥综合征、三甲双酮 - 对甲双酮综合征、胎儿酒精综合征。产前接触海洛因和吗啡主要会干扰大脑发育。药物成瘾,如产后戒断综合征,主要是由于被动接触麻醉药品(海洛因、美沙酮)、镇静催眠药(巴比妥类、地西泮、氯氮卓)和酒精。香烟烟雾会导致第三组副作用,即胎儿生长受限和早产。孕期滥用咖啡或使用大麻未观察到对人类胎儿有副作用。