Alonso M C, Torres A, Solana R, Manzanares M R, Peña J
Rev Esp Oncol. 1982;29(4):717-25.
The authors investigate the efficacy of the immune system along the AKR/J mouse life span. They employ the phytohemagglutinin (PHA)-induced lymphoblastic transformation test. The response is compared with the immune response obtained in BALB/C mice of the corresponding age. The blastic transformation was significatively lower at 15, 25 and 35 weeks in the AKR/J mouse than in the BALB/C mouse. At the age of 45 weeks the AKR/J mouse shows an increased proportion of lymphocytes in the thymus and spleen, a weight increase of these organs, and an augmented lymphoblastic transformation in response to PHA. This phenomena are not observed in the BALB/C mouse. When macrophages are removed from the lymphocytes preparation, the PHA-induced blastic transformation of lymphocytes is not produced at any age in either AKR/J or BALB/C mice strains.
作者研究了整个AKR/J小鼠生命周期中免疫系统的功效。他们采用了植物血凝素（PHA）诱导的淋巴细胞转化试验。将该反应与相应年龄的BALB/C小鼠获得的免疫反应进行比较。在15、25和35周时，AKR/J小鼠的细胞转化明显低于BALB/C小鼠。在45周龄时，AKR/J小鼠胸腺和脾脏中的淋巴细胞比例增加，这些器官重量增加，对PHA的淋巴细胞转化增强。在BALB/C小鼠中未观察到这种现象。当从淋巴细胞制剂中去除巨噬细胞时，在AKR/J或BALB/C小鼠品系的任何年龄都不会产生PHA诱导的淋巴细胞转化。
