Kashlakova N V, Lisukov I A, Tsyrlova I G, Vasil'ev N V, Kozlov V A
Biull Eksp Biol Med. 1988 Feb;105(2):184-6.
Blast cells obtained from the "erythropoietic spleen" of FG-stimulated young mice and cells accumulating in the spleens of preleukemic AKR mice have a marked suppressive effect on spontaneous and mitogen-induced proliferation of young mouse splenocytes in vitro and suppress the development of humoral immune response in immunized recipients during syngeneic transfer in vivo. Some disturbances in erythron system in preleukemic AKR mice manifested in the accumulation of immature erythroid precursors which are suppressors of immunocompetent lymphocytes are suggested to be a pathogenetic link in the development of leukemia.
从FG刺激的幼鼠“红细胞生成性脾脏”中获得的原始细胞以及白血病前期AKR小鼠脾脏中积累的细胞，对幼鼠脾细胞在体外的自发增殖和丝裂原诱导的增殖具有显著的抑制作用，并且在体内同基因转移过程中抑制免疫受体中体液免疫反应的发展。白血病前期AKR小鼠红细胞系统的一些紊乱表现为未成熟红细胞前体的积累，这些前体是免疫活性淋巴细胞的抑制剂，提示这可能是白血病发生发展中的一个致病环节。
