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高龄母亲所生子女患I型糖尿病的发病率增加。

Increased incidence of type I diabetes in children of older mothers.

作者信息

Flood T M, Brink S J, Gleason R E

出版信息

Diabetes Care. 1982 Nov-Dec;5(6):571-3. doi: 10.2337/diacare.5.6.571.

DOI:10.2337/diacare.5.6.571
PMID:6985452
Abstract

Analysis of chart data in a large series of patients with juvenile-onset, type I diabetes shows a highly significant (P less than 0.001) increased incidence in the children born to older mothers. Diabetes was also much more frequent in the late-birth-order siblings, and this appears to be an alternative expression of advanced maternal age. This observation suggests that there may be a subset of children who eventually develop type I diabetes and are at increased risk by virtue of being born to older mothers.

摘要

对一大群青少年期发病的I型糖尿病患者的图表数据进行分析后发现,母亲年龄较大的孩子患糖尿病的发病率显著增加(P<0.001)。晚出生顺序的兄弟姐妹患糖尿病的情况也更为常见,这似乎是母亲年龄较大的另一种表现形式。这一观察结果表明,可能存在一部分最终会患I型糖尿病的儿童,他们因母亲年龄较大而患病风险增加。

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