Sobel A, Grzywa M
Oddział Chorób Wewnetrznych, Szpital Wojewódzki Nr 2 w Rzeszowie.
Pol Arch Med Wewn. 1994 Apr;91(4):274-81.
The aim of the study was to determine whether advanced maternal age (over 35 years) on birth of a child had any influence on the incidence of IDDM in her offspring. The analysis has also taken into account the presence of other factors which may have some bearing on the incidence of the disease. They are the following: viral infections prior to the onset of IDDM, sequence of the affected child's birth in relation to other siblings, and family history of diabetes. The study included 243 persons who fell ill with IDDM at the age of 0-29 years in the period of January 1st 1980 to December 31st 1992 and the pair matched control group. They were all residents of the Rzeszów province at the onset of the disease. We have found that a positive family history of diabetes, viral infection especially epidemic parotitis, and parity are the factors which increase the incidence of IDDM. Advanced maternal age, over 35 years on child's birth, along with the above-mentioned factors, increase the incidence of IDDM.
该研究的目的是确定产妇高龄（35岁以上）分娩对其子女患胰岛素依赖型糖尿病（IDDM）的发病率是否有任何影响。分析还考虑了可能与该病发病率有关的其他因素。它们如下：IDDM发病前的病毒感染、患病儿童相对于其他兄弟姐妹的出生顺序以及糖尿病家族史。该研究纳入了1980年1月1日至1992年12月31日期间0至29岁患IDDM的243人以及配对的对照组。他们在疾病发作时均为热舒夫省居民。我们发现糖尿病家族史阳性、病毒感染尤其是流行性腮腺炎以及产次是增加IDDM发病率的因素。产妇高龄（孩子出生时超过35岁）与上述因素一起会增加IDDM的发病率。
