类固醇硫酸酯酶基因位点的区域定位
Regional assignment of the gene locus for steroid sulfatase.
作者信息
Müller C R, Westerveld A, Migl B, Franke W, Ropers H H
出版信息
Hum Genet. 1980;54(2):201-4. doi: 10.1007/BF00278972.
PMID:6985463
Abstract
The gene locus for steroid sulfatase, deficiency of which causes X-linked ichthyosis, is assigned to Xp11 leads to Xpter by analysis of 24 man-Chinese hamster somatic cell hybrids. High steroid sulfatase activity in a hybrid clone having retained only part of Xq is explained by demonstration of an additional late-replicating human X chromosome. This observation confirms previous evidence for noninactivation of the STS locus.
摘要
类固醇硫酸酯酶的基因位点（其缺乏会导致X连锁鱼鳞病）通过对24个人-中国仓鼠体细胞杂种的分析被定位到Xp11至Xpter。在仅保留部分Xq的杂种克隆中出现高类固醇硫酸酯酶活性，这是通过证明存在一条额外的晚复制人类X染色体来解释的。这一观察结果证实了之前关于STS基因座未失活的证据。
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