X连锁类固醇硫酸酯酶：男性和女性基因剂量差异的证据。

X-linked steroid sulfatase: evidence for different gene-dosage in males and females.

作者信息

Müller C R, Migl B, Traupe H, Ropers H H

出版信息

Hum Genet. 1980;54(2):197-9. doi: 10.1007/BF00278971.

Abstract

Steroid sulfatase (STS) activities in female fibroblast strains are significantly higher than in male strains, as determined by cleavage of dehydroepiandrosterone sulfate. The difference is probably not due to hormonal control of gene expression, but suggests that for this X-linked locus there is no gene dosage compensation.

摘要

通过硫酸脱氢表雄酮的裂解测定发现，雌性成纤维细胞系中的类固醇硫酸酯酶（STS）活性显著高于雄性细胞系。这种差异可能并非由于基因表达的激素调控，而是表明对于这个X连锁基因座不存在基因剂量补偿。