癌症转移的发病机制。

Nature. 1980 Jan 10;283(5743):139-46. doi: 10.1038/283139a0.

Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process.

转移并非源于原发肿瘤释放的细胞随机存活，而是源于具有特定特性的高转移细胞亚群的选择性生长，这些特性使它们能够完成转移过程的每一步。