Inhibition of glucagon and insulin secretion from the perfused rat pancreas by a B-cell-selective somatostatin analog.
作者信息
Weir G C, Schwarz J A, Mathe C J
出版信息
Metabolism. 1980 Jan;29(1):68-70. doi: 10.1016/0026-0495(80)90100-6.
PMID:6986012
Abstract
The isolated perfused rat pancreas was used to study the effects of somatostatin and the analog des-Asn5-[D-Trps, D-Ser13]-somatostatin on arginine-stimulated insulin and glucagon secretion. Even though the analog was found to inhibit glucagon secretion at concentrations of 10 and 100 ng/ml, it had a relatively more inhibitory effect on the B cell than on the A cell than did somatostatin itself. These data suggest that the A- and B-cell receptors for these two peptides differ.
摘要
相似文献
1
Inhibition of glucagon and insulin secretion from the perfused rat pancreas by a B-cell-selective somatostatin analog.
Metabolism. 1980 Jan;29(1):68-70. doi: 10.1016/0026-0495(80)90100-6.
2
Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ.在原位灌注的大鼠胰腺中，生长抑素对胰高血糖素和胰岛素分泌的抑制作用。
Endocrinology. 1975 Feb;96(2):370-4. doi: 10.1210/endo-96-2-370.
3
Effect of glucagon antiserum on somatostatin, glucagon and insulin release from the isolated perfused rat pancreas.胰高血糖素抗血清对离体灌注大鼠胰腺中生长抑素、胰高血糖素和胰岛素释放的影响。
Peptides. 1982 Mar-Apr;3(2):175-82. doi: 10.1016/0196-9781(82)90048-1.
4
Starvation-induced changes of somatostatin, glucagon, and insulin secretion from the isolated perfused rat pancreas.饥饿诱导的离体灌注大鼠胰腺中生长抑素、胰高血糖素和胰岛素分泌的变化。
Diabetes. 1980 Apr;29(4):323-5. doi: 10.2337/diab.29.4.323.
5
Differential effects of somatostatin analogues on alpha- and beta-cells of the pancreas.
Am J Physiol. 1979 Feb;236(2):E123-8. doi: 10.1152/ajpendo.1979.236.2.E123.
6
Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas.咪唑啉衍生物RX871024对离体灌注大鼠胰腺胰岛素、胰高血糖素和生长抑素分泌的影响。
Biochem Biophys Res Commun. 1998 Nov 9;252(1):162-5. doi: 10.1006/bbrc.1998.9635.
7
Effects of PHI on hormonal secretion from perfused rat pancreas.苯甲脒对灌注大鼠胰腺激素分泌的影响。
Am J Physiol. 1983 Oct;245(4):E313-7. doi: 10.1152/ajpendo.1983.245.4.E313.
8
Somatostatin analogs inhibit somatostatin release.生长抑素类似物抑制生长抑素释放。
Endocrinology. 1979 May;104(5):1270-3. doi: 10.1210/endo-104-5-1270.
9
Insulin, glucagon, and somatostatin secretion from isolated perfused rat and chicken pancreas-duodenum.来自分离灌注的大鼠和鸡胰腺十二指肠的胰岛素、胰高血糖素和生长抑素分泌。
Am J Physiol. 1980 Feb;238(2):E150-6. doi: 10.1152/ajpendo.1980.238.2.E150.
10
Effect of ventromedial hypothalamic lesions on the secretion of somatostatin, insulin, and glucagon by the perfused rat pancreas.下丘脑腹内侧核损伤对灌注大鼠胰腺生长抑素、胰岛素和胰高血糖素分泌的影响。
Metabolism. 1980 Oct;29(10):986-90. doi: 10.1016/0026-0495(80)90044-x.
Zotero 插件