Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis.

One hundred patients with eczema/atopic dermatitis were treated in a double-blind, paired-comparison fashion with clocortolone pivalate 0.1 percent cream and the placebo cream base. Results with the active agent were statistically significantly superior in all objective and subjective rating parameters. No adverse reactions were observed and patient acceptance of both test medications was excellent. Discussions of paired-comparison methodology and placebo response are included herein.