Ono M, Oka T
Science. 1980 Mar 21;207(4437):1367-9. doi: 10.1126/science.6986657.
The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.
胰岛素、皮质醇和催乳素之间的相互作用可诱导来自成熟处女小鼠的培养乳腺外植体中酪蛋白和α-乳白蛋白的合成。已发现体外最大程度诱导这两种乳蛋白所需的皮质醇最佳浓度之间存在显著差异：α-乳白蛋白为3×10⁻⁸摩尔，酪蛋白为3×10⁻⁶摩尔。此外，10⁻⁷至10⁻⁵摩尔的皮质醇会逐渐抑制α-乳白蛋白的积累。皮质醇的这种差异作用可能部分解释了孕期两种蛋白质的异步合成。
