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大剂量化疗、放疗及骨髓移植后发生的致死性肝静脉闭塞病

Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation.

作者信息

Woods W G, Dehner L P, Nesbit M E, Krivit W, Coccia P F, Ramsay N K, Kim T H, Kersey J H

出版信息

Am J Med. 1980 Feb;68(2):285-90. doi: 10.1016/0002-9343(80)90368-x.

Abstract

In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.

摘要

两名因潜在恶性肿瘤接受骨髓移植的患者发生了致命的肝静脉闭塞性疾病。两人在移植前均接受了包括阿糖胞苷在内的大量化疗以及全身照射。对于接受癌症化疗后出现肝肿大、腹水和肝功能检查恶化的患者,应考虑肝静脉闭塞性疾病的诊断。

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