Katz M, Shapiro W B, Porush J G, Chou S Y, Israel V
Am J Obstet Gynecol. 1980 Mar 1;136(5):676-8. doi: 10.1016/0002-9378(80)91023-6.
Uteroplacental ischemia is associated with uterine renin release in pregnant nephrectomized rabbits. In the present study, uterine and renal renin release after uteroplacental ischemia were investigated in 10 Australian white rabbits at 24 to 28 days' gestation. Pentobarbital was administered, and both uterine arteries were ligated close to their origins. Blood samples were taken for plasma renin activity (PRA) determinations from the femoral artery, uterine vein, and right renal vein before ligation and at 30 and 60 minutes after ligation. Mean arterial blood pressure (MAP) was monitored throughout. In five additional pregnant rabbits renal blood flow (RBF) was measured with an electromagnetic flowmeter. The preligation uterine vein-artery PRA difference was not significant (1.9 +/- 1.1 ng/ml/hr). Postligation uterine vein-artery PRA was 11.4 +/- 3.2 at 30 minutes and 6.6 +/- 1.9 ng/ml/hr at 90 minutes (p less than 0.02). Preligation renal vein-artery PRA was 32.3 +/- 10.5 ng/ml/hr (p less than 0.02) and did not change significantly after ligation. MAP remained stable and RBF was unchanged after uterine artery ligation. These observations confirm the finding that the kidney is the primary source of renin in the normal pregnant rabbit and demonstrate that following acute uteroplacental ischemia there is significant uterine renin release even when the kidneys are intact.
子宫胎盘缺血与妊娠肾切除兔子的子宫肾素释放有关。在本研究中，对10只妊娠24至28天的澳大利亚白兔进行了子宫胎盘缺血后子宫和肾脏肾素释放情况的研究。给予戊巴比妥，双侧子宫动脉在其起始处附近结扎。在结扎前、结扎后30分钟和60分钟，从股动脉、子宫静脉和右肾静脉采集血样测定血浆肾素活性（PRA）。全程监测平均动脉血压（MAP）。另外对5只妊娠兔子用电磁流量计测量肾血流量（RBF）。结扎前子宫静脉 - 动脉PRA差值不显著（1.9±1.1 ng/ml/hr）。结扎后30分钟子宫静脉 - 动脉PRA为11.4±3.2，90分钟时为6.6±1.9 ng/ml/hr（p＜0.02）。结扎前肾静脉 - 动脉PRA为32.3±10.5 ng/ml/hr（p＜0.02），结扎后无显著变化。子宫动脉结扎后MAP保持稳定，RBF无改变。这些观察结果证实了正常妊娠兔子中肾脏是肾素主要来源这一发现，并表明在急性子宫胎盘缺血后，即使肾脏完好，子宫也会有显著的肾素释放。
