[Experimental meningoencephalitis in mice caused by Klebsiella pneumoniae as a chemotherapeutic model].

The possibility of reproducing meningoencephalitis caused by Kl. Pneumoniae was studied on 1070 albino mice. The infection development was estimated by the clinical picture of the disease, survival of the animals, bacteriological and pathomorphological examination of the brain and internal organs. For reproduction of meningoencephalitis with the lethal outcome it is enough to use an infecting dose of 250 microbial cells. The pathomorphological changes in the brain tissue and the results of the pathogen isolation from the specimes of the brain and internal organs are described in dynamics. The role of vascular affection in the disease pathogenesis is indicated. Experimental meningoencephalitis of mice differs by its pathogenesis and pathomorphological picture from Klebsiella purulent leptomeningitis of rabbits and purulent meningoencephalitis of mice caused by Ps. aeruginosa. The model is recommended for use in the studies on the activity of chemotherapeutic drugs.