Brolin R E, Ravitch M M
Arch Surg. 1980 Mar;115(3):339-43. doi: 10.1001/archsurg.1980.01380030083020.
This study was devised to disclose any harmful effect of stimulation of the bowel by neostigmine (Prostigmin), alone, or in combination with castor oil in 220 canine anastomoses (60 stapled, 60 two-layer silk and catgut inverted, and 100 one-layer silk everted) performed in enteroenterostomies, ileocolostomies, and colocolostomies. Two techniques were used for the one-layer everted anastomoses--a through-and-through simple interrupted ("Navy") and a horizontal mattress interrupted. One hundred and ten experimental dogs received neostigmine intramuscularly on each of the first three postoperative days. Forty-five of these dogs also received castor oil orally on the first two postoperative days. Peristalsis induced by neostigmine, alone or in combination with castor oil, has no deleterious effect on stapled or conventional two-layer inverted or one-layer Navy everted anastomoses of small bowel or colon, but adversely affects the one-layer "mattress" closure in the colon. Dogs with induced peristalsis had their first evacuation sooner and ate sooner.
本研究旨在揭示新斯的明（普洛斯的明）单独或与蓖麻油联合刺激肠道对220例犬肠吻合术（60例吻合器吻合、60例两层丝线和肠线外翻吻合以及100例单层丝线外翻吻合）的有害影响，这些吻合术包括小肠吻合术、回结肠吻合术和结肠吻合术。单层外翻吻合采用了两种技术——贯穿式单纯间断缝合（“海军”式）和水平褥式间断缝合。110只实验犬在术后头三天每天接受一次新斯的明肌肉注射。其中45只犬在术后前两天还口服了蓖麻油。新斯的明单独或与蓖麻油联合诱导的肠蠕动对小肠或结肠的吻合器吻合、传统两层外翻吻合或单层“海军”式外翻吻合均无有害影响，但对结肠的单层“褥式”缝合有不利影响。有诱导肠蠕动的犬首次排便更早，进食也更早。
