McAllen M K, Portillo P R, Parr E J, Seaton A, Engler C
Br J Dis Chest. 1980 Jan;74(1):32-6.
Flunisolide nasal spray has been compared with placebo and with beclomethasone dipropionate in the treatment of perennial rhinitis. A double-blind, cross-over study in 26 patients comparing intranasal flunisolide (total dose 300 microgram/day) with placebo showed superiority of the active preparation in the relief of sneezing, stuffiness and runny nose. Physicians and patients significantly preferred the active spray. Side-effects on both sprays were mainly confined to transient nasal irritation. Plasma cortisol levels did not change significantly during the trial. A single-blind, cross-over study in 34 patients comparing flunisolide and beclomethasone dipropionate showed relief of sneezing, stuffiness, runny nose and nose-blowing with both medications. There were no differences between the effects of the two preparations. Physicians and patients favoured the drugs equally. Side-effects were minor.
在常年性鼻炎的治疗中，已对氟尼缩松鼻喷雾剂与安慰剂及二丙酸倍氯米松进行了比较。一项针对26例患者的双盲交叉研究比较了鼻内使用氟尼缩松（总剂量300微克/天）与安慰剂，结果显示活性制剂在缓解打喷嚏、鼻塞和流涕方面更具优势。医生和患者明显更倾向于活性喷雾剂。两种喷雾剂的副作用主要局限于短暂的鼻腔刺激。试验期间血浆皮质醇水平无显著变化。一项针对34例患者的单盲交叉研究比较了氟尼缩松和二丙酸倍氯米松，结果显示两种药物在缓解打喷嚏、鼻塞、流涕和擤鼻方面均有效果。两种制剂的效果无差异。医生和患者对这两种药物的青睐程度相同。副作用较小。
