Jörnvall H
Experientia Suppl. 1980;36:126-48. doi: 10.1007/978-3-0348-5419-1_4.
This chapter describes known characteristics of evolutionary changes in individual dehydrogenases, as well as possible relationships among this group of enzymes. Data from primary structures are correlated with those from other observations. Variations in the amino acid sequences demonstrate functional properties, and can be interpreted in relation to conformational aspects, subunit arrangements and enzyme stabilities. Different types of isozyme developments have occurred and show functional fixations at various levels. They define isozyme patterns of general significance in protein evolution. Sequence similarities may be found between different segments. They are analyzed in relation to known conformations, subunit sizes, species divergence and genetic mechanisms. A wide-ranging evolutionary model is discussed relating dehydrogenases and some other oligomeric enzymes to a distant, frequently remodelled ancestral building unit of repetitive occurrence.
本章描述了个体脱氢酶进化变化的已知特征，以及这组酶之间可能的关系。一级结构的数据与其他观察结果相关联。氨基酸序列的变化展示了功能特性，并可根据构象方面、亚基排列和酶稳定性进行解释。已经出现了不同类型的同工酶发育，并在不同水平上表现出功能固定。它们定义了蛋白质进化中具有普遍意义的同工酶模式。不同片段之间可能存在序列相似性。它们根据已知的构象、亚基大小、物种差异和遗传机制进行分析。讨论了一个广泛的进化模型，该模型将脱氢酶和其他一些寡聚酶与一个遥远的、经常重塑的重复出现的祖先构建单元联系起来。
