Jörnvall H
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2295-8. doi: 10.1073/pnas.70.8.2295.
The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structures and subunit sizes. Some regions show no significant similarities, but long segments within the N-terminal parts of the molecules are homologous, suggesting a common and important function for these segments. Ancestral connections between some different dehydrogenases can be concluded and the degree of evolutionary changes may be estimated.
酵母乙醇脱氢酶约一半蛋白质链的一级结构已被确定，并与其他脱氢酶的氨基酸序列进行了比较。发现该酶与马肝乙醇脱氢酶有较远的亲缘关系，尽管这两种蛋白质具有不同的四级结构和亚基大小。有些区域没有明显的相似性，但分子N端部分的长片段是同源的，这表明这些片段具有共同且重要的功能。可以推断出一些不同脱氢酶之间的祖先联系，并估计进化变化的程度。
