1,2 - 二溴 - 3 - 氯丙烷（DBCP）诱导雄性大鼠产生的显性致死突变。
Dominant lethal mutation induced in male rats by 1,2-dibromo-3-chloropropane (DBCP).
作者信息
Teramoto S, Saito R, Aoyama H, Shirasu Y
出版信息
Mutat Res. 1980 Jan;77(1):71-8. doi: 10.1016/0165-1218(80)90122-6.
PMID:6987512
Abstract
1,2-Dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP), soil fumigants, were investigated for their potential mutagenicity by dominant lethal studies in the rat and mouse. Dominant lethal mutation was induced by DBE in neither of the species. DBCP, on the other hand, induced dominant lethals in rats in the post-meiotic stage of spermatogenesis, especially in the early spermatid stage. However, DBCP did not cause dominant lethals in mice.
摘要
对土壤熏蒸剂1,2 - 二溴乙烷（DBE）和1,2 - 二溴 - 3 - 氯丙烷（DBCP）进行了研究，通过在大鼠和小鼠中进行显性致死研究来探究它们的潜在致突变性。DBE在这两种物种中均未诱导显性致死突变。另一方面，DBCP在大鼠精子发生的减数分裂后阶段，尤其是在早期精子细胞阶段诱导了显性致死。然而，DBCP在小鼠中并未导致显性致死。
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