Merenstein G B, Todd W A, Brown G, Yost C C, Luzier T
Obstet Gynecol. 1980 Mar;55(3):315-8.
A randomized controlled investigation was undertaken to evaluate the role of maternal oral antibiotic therapy in decreasing the incidence of maternal and neonatal colonization at term with group B beta-hemolytic streptococcus (GB-BHS). Data were collected to determine the optimum transfer media and the colonization rate in the study population. At delivery 1441 maternal-infant pairs were evaluated. One hundred sixty-eight women (11.6%) and 55 infants (3.8%) were colonized. Forty-four women colonized with GB-BHS at 38 weeks' gestation were randomly assigned to a treatment (500 mg potassium penicillin or erythromycin ethylsuccinate q.i.d.) or a control group to determine the value of antepartum oral antibiotic therapy in preventing infant colonization. There was a significant reduction in maternal (P = 0.008) and infant (P = 0.004) colonization rates in the treatment group. There were no observed complications of antibiotic therapy in mothers or infants. This study suggests that routine cultures for GB-BHS should be done at 38 weeks' gestation. Mothers colonized at this time may be considered candidates for prophylactic antibiotic treatment.
开展了一项随机对照研究，以评估母体口服抗生素治疗在降低足月时B族β溶血性链球菌（GB - BHS）母婴定植发生率中的作用。收集数据以确定最佳转运培养基和研究人群中的定植率。分娩时评估了1441对母婴。168名女性（11.6%）和55名婴儿（3.8%）被定植。44名在妊娠38周时被GB - BHS定植的女性被随机分配到治疗组（500毫克青霉素钾或琥乙红霉素，每日四次）或对照组，以确定产前口服抗生素治疗在预防婴儿定植中的价值。治疗组中母体（P = 0.008）和婴儿（P = 0.004）的定植率显著降低。未观察到母亲或婴儿有抗生素治疗并发症。这项研究表明，应在妊娠38周时进行GB - BHS的常规培养。此时被定植的母亲可被视为预防性抗生素治疗的候选者。
